Concentrations of Voriconazole in Healthy and Inflamed Lung in Rats | Zendy

Christian Joukhadar | Zendy; Christiane Thallinger | Zendy; Wolfgang Pöppl | Zendy; Florian M. Kovar | Zendy; K. H. Konz | Zendy; Samir M. Joukhadar | Zendy; Friederike Traunmüller | Zendy

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Concentrations of Voriconazole in Healthy and Inflamed Lung in Rats

Author(s) -

Christian Joukhadar,

Christiane Thallinger,

Wolfgang Pöppl,

Florian M. Kovar,

K. H. Konz,

Samir M. Joukhadar,

Friederike Traunmüller

Publication year - 2009

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.00885-08

Subject(s) - voriconazole , pharmacokinetics , microdialysis , lung , medicine , plasma concentration , skeletal muscle , pharmacology , pathology , antifungal , dermatology , central nervous system

By utilizing the microdialysis technique, we investigated the pharmacokinetic profile of voriconazole in the interstitium of the lungs and skeletal muscle tissue of rats after a single intravenous dose under healthy and inflammatory conditions. As expected, voriconazole penetrated excellently into the interstitium of tissues, and its levels were descriptively almost identical to free concentration-versus-time profiles in plasma.

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