In Vitro Study of Candida tropicalis Isolates Exhibiting Paradoxical Growth in the Presence of High Concentrations of Caspofungin | Zendy

G. Sóczó | Zendy; Gábor Kardos | Zendy; Ivan Varga | Zendy; B Kelentey | Zendy; Rudolf Gesztelyi | Zendy; László Majoros | Zendy

Open Access

In Vitro Study of Candida tropicalis Isolates Exhibiting Paradoxical Growth in the Presence of High Concentrations of Caspofungin

Author(s) -

G. Sóczó,

Gábor Kardos,

Ivan Varga,

B Kelentey,

Rudolf Gesztelyi,

László Majoros

Publication year - 2007

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.00880-07

Subject(s) - caspofungin , candida tropicalis , microbiology and biotechnology , in vitro , biology , antibiotics , fungi imperfecti , antifungal , fungicide , biochemistry , amphotericin b , botany

Paradoxical growth was noted in RPMI 1640 and antibiotic medium 3 in the case of 14 and 1 of 15 Candida tropicalis strains, respectively, at a caspofungin concentration of 12.5 microg/ml using minimum fungicidal concentration tests. Time-kill assays showed that against isolates killed at lower concentrations, caspofungin at a concentration of 12.5 microg/ml was only fungistatic.

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