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The nucleotide sequences of five plasmids from oneKlebsiella oxytoca isolate were determined using the PacBio RS II system. Plasmid analysis revealed thatbla NDM-1 was carried on an IncX3 plasmid. Thebla IMP-4 andbla KPC-2 genes were located on IncN and IncP-6 plasmids, respectively. Comparative sequence analysis highlighted the successful spread of carbapenemase-harboring plasmids among different enterobacterial species. We report for the first time, to our knowledge, coproducing NDM-1, KPC-2, and IMP-4 carbapenemases on aK. oxytoca isolate.

First Report of Klebsiella oxytoca Strain Simultaneously Producing NDM-1, IMP-4, and KPC-2 Carbapenemases