First Report of Klebsiella oxytoca Strain Simultaneously Producing NDM-1, IMP-4, and KPC-2 Carbapenemases | Zendy

Juan Wang | Zendy; Min Yuan | Zendy; Hai Chen | Zendy; Xia Chen | Zendy; Yuan-chun Jia | Zendy; Xiong Zhu | Zendy; Li Bai | Zendy; Xue Bai | Zendy; Séamus Fanning | Zendy; Jinxing Lu | Zendy; Li Juan | Zendy

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First Report of Klebsiella oxytoca Strain Simultaneously Producing NDM-1, IMP-4, and KPC-2 Carbapenemases

Author(s) -

Juan Wang,

Min Yuan,

Hai Chen,

Xia Chen,

Yuan-chun Jia,

Xiong Zhu,

Li Bai,

Xue Bai,

Séamus Fanning,

Jinxing Lu,

Li Juan

Publication year - 2017

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.00877-17

Subject(s) - klebsiella oxytoca , microbiology and biotechnology , strain (injury) , klebsiella pneumoniae , klebsiella , enterobacteriaceae , ertapenem , biology , klebsiella infections , antibiotics , meropenem , antibiotic resistance , escherichia coli , genetics , gene , anatomy

The nucleotide sequences of five plasmids from oneKlebsiella oxytoca isolate were determined using the PacBio RS II system. Plasmid analysis revealed thatbla NDM-1 was carried on an IncX3 plasmid. Thebla IMP-4 andbla KPC-2 genes were located on IncN and IncP-6 plasmids, respectively. Comparative sequence analysis highlighted the successful spread of carbapenemase-harboring plasmids among different enterobacterial species. We report for the first time, to our knowledge, coproducing NDM-1, KPC-2, and IMP-4 carbapenemases on aK. oxytoca isolate.

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