Synergistic Activity of Colistin-Containing Combinations against Colistin-Resistant Enterobacteriaceae | Zendy

Thea Brennan-Krohn | Zendy; Alejandro Pironti | Zendy; James E. Kirby | Zendy

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Synergistic Activity of Colistin-Containing Combinations against Colistin-Resistant Enterobacteriaceae

Author(s) -

Thea Brennan-Krohn,

Alejandro Pironti,

James E. Kirby

Publication year - 2018

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.00873-18

Subject(s) - colistin , enterobacteriaceae , antibiotics , microbiology and biotechnology , mcr 1 , drug resistance , carbapenem resistant enterobacteriaceae , multiple drug resistance , enterobacteriaceae infections , biology , medicine , escherichia coli , biochemistry , gene

Resistance to colistin, a polypeptide drug used as an agent of last resort for the treatment of infections caused by multidrug-resistant (MDR) and extensively drug-resistant (XDR) Gram-negative bacteria, including carbapenem-resistantEnterobacteriaceae (CRE), severely limits treatment options and may even transform an XDR organism into one that is pan-resistant. We investigated the synergistic activity of colistin in combination with 19 antibiotics against a collection of 20 colistin-resistantEnterobacteriaceae isolates, 15 of which were also CRE.

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