Polymorphism of Polymeric Amino Acid Regions in Fungal Proteins and Correlation with Altered Echinocandin and Azole Susceptibility | Zendy

Krishna K. Challa | Zendy; Tom Edlind | Zendy; Säntosh K. Katiyar | Zendy

Open Access

Polymorphism of Polymeric Amino Acid Regions in Fungal Proteins and Correlation with Altered Echinocandin and Azole Susceptibility

Author(s) -

Krishna K. Challa,

Tom Edlind,

Säntosh K. Katiyar

Publication year - 2018

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.00870-18

Subject(s) - azole , echinocandin , polymorphism (computer science) , chemistry , biology , amino acid , biochemistry , microbiology and biotechnology , antifungal , fluconazole , genotype , gene

Polymorphism of polymeric amino acid (polyX) regions within fungal proteins represents a potential mechanism for rapid genotypic adaptation to environmental pressures, including antifungal exposure. Polyglutamine (polyQ) was the most abundant repeat in the proteomes of 8 diverse fungal species and was preferentially found in regulatory proteins.

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