Genomic Analysis Identifies Novel Pseudomonas aeruginosa Resistance Genes under Selection during Inhaled Aztreonam Therapy In Vivo | Zendy

Kathryn McLean | Zendy; Duankun Lee | Zendy; Elizabeth A. Holmes | Zendy; Kelsi Penewit | Zendy; Adam Waalkes | Zendy; Mingxin Ren | Zendy; Samuel A. Lee | Zendy; J. Gasper | Zendy; Colin Manoil | Zendy; Stephen J. Salipante | Zendy

Open Access

Genomic Analysis Identifies Novel Pseudomonas aeruginosa Resistance Genes under Selection during Inhaled Aztreonam Therapy In Vivo

Author(s) -

Kathryn McLean,

Duankun Lee,

Elizabeth A. Holmes,

Kelsi Penewit,

Adam Waalkes,

Mingxin Ren,

Samuel A. Lee,

J. Gasper,

Colin Manoil,

Stephen J. Salipante

Publication year - 2019

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.00866-19

Subject(s) - aztreonam , pseudomonas aeruginosa , in vivo , biology , gene , microbiology and biotechnology , selection (genetic algorithm) , genetics , bacteria , ceftazidime , artificial intelligence , computer science

Inhaled aztreonam is increasingly used for chronicPseudomonas aeruginosa suppression in patients with cystic fibrosis (CF), but the potential for that organism to evolve aztreonam resistance remains incompletely explored. Here, we performed genomic analysis of clonally related pre- and posttreatment CF clinical isolate pairs to identify genes that are under positive selection during aztreonam therapyin vivo .

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