Contribution of Novel Amino Acid Alterations in PmrA or PmrB to Colistin Resistance in mcr -Negative Escherichia coli Clinical Isolates, Including Major Multidrug-Resistant Lineages O25b:H4-ST131- H 30Rx and Non-x | Zendy

Toyotaka Sato | Zendy; Tsukasa Shiraishi | Zendy; Yoshiki Hiyama | Zendy; Hiroyuki Honda | Zendy; Masaaki Shinagawa | Zendy; Masaru Usui | Zendy; Koji Kuronuma | Zendy; Naoya Masumori | Zendy; Satoshi Takahashi | Zendy; Yutaka Tamura | Zendy; Shinichi Yokota | Zendy

Open Access

Contribution of Novel Amino Acid Alterations in PmrA or PmrB to Colistin Resistance in mcr -Negative Escherichia coli Clinical Isolates, Including Major Multidrug-Resistant Lineages O25b:H4-ST131- H 30Rx and Non-x

Author(s) -

Toyotaka Sato,

Tsukasa Shiraishi,

Yoshiki Hiyama,

Hiroyuki Honda,

Masaaki Shinagawa,

Masaru Usui,

Koji Kuronuma,

Naoya Masumori,

Satoshi Takahashi,

Yutaka Tamura,

Shinichi Yokota

Publication year - 2018

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.00864-18

Subject(s) - colistin , microbiology and biotechnology , biology , escherichia coli , mutant , plasmid , antibiotics , gene , biochemistry

Colistin is a last-line drug for multidrug-resistant Gram-negative bacteria. We previously reported four plasmid-mediated colistin resistance (mcr ) gene-negative colistin-resistantEscherichia coli clinical isolates, including the major pathogenic and fluoroquinolone-resistant strains O25b:H4-ST131-H 30Rx (isolates SRE34 and SRE44; MIC for colistin = 16 mg/liter), non-x (SME296; MIC = 8 mg/liter), and O18-ST416 (SME222; MIC = 4 mg/liter).

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