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The fight against resistance to antifungal drugs requires a better understanding of the underlying cellular mechanisms. In order to gain insight into the mechanisms leading to antifungal drug resistance, we performed a genetic screen on a model organism,Schizosaccharomyces pombe , to identify genes whose overexpression caused resistance to antifungal drugs, including clotrimazole and terbinafine.

antimicrobial agents and chemotherapy

Dysfunction of Prohibitin 2 Results in Reduced Susceptibility to Multiple Antifungal Drugs via Activation of the Oxidative Stress-Responsive Transcription Factor Pap1 in Fission Yeast