Dysfunction of Prohibitin 2 Results in Reduced Susceptibility to Multiple Antifungal Drugs via Activation of the Oxidative Stress-Responsive Transcription Factor Pap1 in Fission Yeast | Zendy

Qiannan Liu | Zendy; Fan Yao | Zendy; Guanglie Jiang | Zendy; Min Xu | Zendy; Si Chen | Zendy; Lina Zhou | Zendy; Norihiro Sakamoto | Zendy; Takayoshi Kuno | Zendy; Yue Fang | Zendy

Open Access

Dysfunction of Prohibitin 2 Results in Reduced Susceptibility to Multiple Antifungal Drugs via Activation of the Oxidative Stress-Responsive Transcription Factor Pap1 in Fission Yeast

Author(s) -

Qiannan Liu,

Fan Yao,

Guanglie Jiang,

Min Xu,

Si Chen,

Lina Zhou,

Norihiro Sakamoto,

Takayoshi Kuno,

Yue Fang

Publication year - 2018

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.00860-18

Subject(s) - schizosaccharomyces pombe , antifungal , terbinafine , transcription factor , clotrimazole , drug resistance , biology , oxidative stress , schizosaccharomyces , antifungal drug , antifungal drugs , yeast , microbiology and biotechnology , pharmacology , gene , saccharomyces cerevisiae , genetics , itraconazole , biochemistry

The fight against resistance to antifungal drugs requires a better understanding of the underlying cellular mechanisms. In order to gain insight into the mechanisms leading to antifungal drug resistance, we performed a genetic screen on a model organism,Schizosaccharomyces pombe , to identify genes whose overexpression caused resistance to antifungal drugs, including clotrimazole and terbinafine.

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