Quantification of Cefepime, Meropenem, Piperacillin, and Tazobactam in Human Plasma Using a Sensitive and Robust Liquid Chromatography-Tandem Mass Spectrometry Method, Part 1: Assay Development and Validation | Zendy

Ronilda D’Cunha | Zendy; Thanh Bach | Zendy; Beth Ann Young | Zendy; Peizhi Li | Zendy; Demet Nalbant | Zendy; Jun Zhang | Zendy; Patricia Winokur | Zendy; Guohua An | Zendy

Open Access

Quantification of Cefepime, Meropenem, Piperacillin, and Tazobactam in Human Plasma Using a Sensitive and Robust Liquid Chromatography-Tandem Mass Spectrometry Method, Part 1: Assay Development and Validation

Author(s) -

Ronilda D’Cunha,

Thanh Bach,

Beth Ann Young,

Peizhi Li,

Demet Nalbant,

Jun Zhang,

Patricia Winokur,

Guohua An

Publication year - 2018

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.00859-18

Subject(s) - cefepime , tazobactam , meropenem , piperacillin , chromatography , piperacillin/tazobactam , protein precipitation , chemistry , therapeutic drug monitoring , selected reaction monitoring , tandem mass spectrometry , sample preparation , analyte , mass spectrometry , pharmacokinetics , antibiotics , pharmacology , medicine , imipenem , antibiotic resistance , biochemistry , biology , bacteria , pseudomonas aeruginosa , genetics

The highly variable pharmacokinetics of β-lactam antibiotics and β-lactamase inhibitors poses a significant challenge to clinicians in ensuring appropriate antibiotic doses in critically ill patients. Therefore, routine monitoring of plasma concentrations is important for individualization of antimicrobial therapy.

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