New Species Genetic Approach To Identify Strains of Mitis Group Streptococci That Are Donors of Rifampin Resistance to Streptococcus pneumoniae | Zendy

María-José Ferrándiz | Zendy; Carmen Ardanuy | Zendy; Josefina Liñares | Zendy; Luz Balsalobre | Zendy; Marı́a Teresa Llorente | Zendy; Adela G. de la Campa | Zendy

Open Access

New Species Genetic Approach To Identify Strains of Mitis Group Streptococci That Are Donors of Rifampin Resistance to Streptococcus pneumoniae

Author(s) -

María-José Ferrándiz,

Carmen Ardanuy,

Josefina Liñares,

Luz Balsalobre,

Marı́a Teresa Llorente,

Adela G. de la Campa

Publication year - 2010

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.00856-10

Subject(s) - rpob , streptococcus mitis , microbiology and biotechnology , biology , streptococcus pneumoniae , streptococcus oralis , streptococcaceae , viridans streptococci , streptococcus , 16s ribosomal rna , antibiotics , genetics , gene , bacteria

Eight rifampin-resistant streptococci of the mitis group were identified at the species level by using a concatenated 16S rRNA gene-sodA-rpoB-hlpA sequence. Characterization of theirrpoB alleles showed single amino acid changes involved in rifampin resistance. Comparison of RpoB sequences from pneumococcal recombinant isolates, viridans isolates, and type strains revealed a species-specific amino acid signature, which allowed it to be ascertained that recombinant RpoBs were originated in genetic interchanges withStreptococcus mitis andStreptococcus oralis .

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