CreC Sensor Kinase Activation Enhances Growth of Escherichia coli in the Presence of Cephalosporins and Carbapenems | Zendy

Yuiko Takebayashi | Zendy; E. SHIRLEY TAYLOR | Zendy; Sam Whitwam | Zendy; Matthew B. Avison | Zendy

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CreC Sensor Kinase Activation Enhances Growth of Escherichia coli in the Presence of Cephalosporins and Carbapenems

Author(s) -

Yuiko Takebayashi,

E. SHIRLEY TAYLOR,

Sam Whitwam,

Matthew B. Avison

Publication year - 2019

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.00846-19

Subject(s) - cefoxitin , cefotaxime , regulon , escherichia coli , cephalosporin , meropenem , microbiology and biotechnology , mutant , antibiotics , overproduction , biology , enterobacteriaceae , chemistry , bacteria , gene , antibiotic resistance , biochemistry , genetics , staphylococcus aureus

Mutants with enhanced growth in the presence of an antibiotic are more difficult to identify than mutants where the antibiotic’s MIC increases, because they are not amenable to lethal selectionin vitro . We report that activatory mutations in the CreC signal sensor enhance growth ofEscherichia coli in the presence of cefoxitin, cefotaxime, and meropenem, without increasing their MICs. Enhanced growth is dependent on overproduction of the inner membranecre regulon protein CreD.

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