Open AccessBK Virus Replication In Vitro: Limited Effect of Drugs Interfering with Viral Uptake and Intracellular Transport
Author(s) -
Parmjeet Randhawa,
Noush Afarin Farasati,
YuChen Huang
Publication year - 2007
Publication title -
antimicrobial agents and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.07
H-Index - 259
eISSN - 1070-6283
pISSN - 0066-4804
DOI - 10.1128/aac.00843-07
Subject(s) - in vitro , virus , viral replication , pathogen , virology , intracellular , nystatin , sialic acid , chemistry , biology , pharmacology , microbiology and biotechnology , biochemistry , antibiotics
BK virus is an important pathogen in kidney transplant recipients. In vitro studies demonstrated slight antiviral activity for chloroquine and nystatin. A sialic acid derivative, BTB11968, was identified as a lead compound for further development.
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