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Clinical isolates ofEscherichia coli andKlebsiella pneumoniae producing extended-spectrum β-lactamases or plasmid-mediated AmpC β-lactamases were screened forqnrA andqnrB genes.QnrB was present in 54 of 54 DHA-1-producingK. pneumoniae isolates and 10 of 45 SHV-12-producing ones, suggesting that the distribution of plasmids conferring resistance to extended-spectrum cephalosporins and quinolones in clinical isolates ofK. pneumoniae is widespread.

antimicrobial agents and chemotherapy

Association of QnrB Determinants and Production of Extended-Spectrum β-Lactamases or Plasmid-Mediated AmpC β-Lactamases in Clinical Isolates of <i>Klebsiella pneumoniae</i>

Association of QnrB Determinants and Production of Extended-Spectrum β-Lactamases or Plasmid-Mediated AmpC β-Lactamases in Clinical Isolates of Klebsiella pneumoniae