In Vitro Activity of APX001A (Manogepix) and Comparator Agents against 1,706 Fungal Isolates Collected during an International Surveillance Program in 2017 | Zendy

Michael A. Pfaller | Zendy; Michael D. Huband | Zendy; Robert K. Flamm | Zendy; Paul Bien | Zendy; Mariana Castanheira | Zendy

Open Access

In Vitro Activity of APX001A (Manogepix) and Comparator Agents against 1,706 Fungal Isolates Collected during an International Surveillance Program in 2017

Author(s) -

Michael A. Pfaller,

Michael D. Huband,

Robert K. Flamm,

Paul Bien,

Mariana Castanheira

Publication year - 2019

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.00840-19

Subject(s) - anidulafungin , micafungin , microbiology and biotechnology , candida krusei , biology , cryptococcus neoformans , broth microdilution , fluconazole , candida glabrata , aspergillus , echinocandin , candida parapsilosis , candida albicans , antifungal , minimum inhibitory concentration , antimicrobial

Current antifungal agents cover a majority of opportunistic fungal pathogens; however, breakthrough invasive fungal infections continue to occur and increasingly involve relatively uncommon yeasts and molds, which often exhibit decreased susceptibility. APX001A (manogepix) is a first-in-class small-molecule inhibitor of the conserved fungal Gwt1 protein. This enzyme is required for acylation of inositol during glycosylphosphatidylinositol anchor biosynthesis.

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