First Report of bla IMP-14 on a Plasmid Harboring Multiple Drug Resistance Genes in Escherichia coli Sequence Type 131 | Zendy

Nicole Stoesser | Zendy; Anna E. Sheppard | Zendy; Gisele Peirano | Zendy; Robert Sebra | Zendy; Tarah Lynch | Zendy; Luke Anson | Zendy; Andrew Kasarskis | Zendy; Mary Motyl | Zendy; Derrick W. Crook | Zendy; Johann Pitout | Zendy

Open Access

First Report of bla _IMP-14 on a Plasmid Harboring Multiple Drug Resistance Genes in Escherichia coli Sequence Type 131

Author(s) -

Nicole Stoesser,

Anna E. Sheppard,

Gisele Peirano,

Robert Sebra,

Tarah Lynch,

Luke Anson,

Andrew Kasarskis,

Mary Motyl,

Derrick W. Crook,

Johann Pitout

Publication year - 2016

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.00840-16

Subject(s) - integron , plasmid , biology , escherichia coli , gene , context (archaeology) , multiple drug resistance , microbiology and biotechnology , pseudomonas aeruginosa , genetics , mcr 1 , enterobacteriaceae , drug resistance , insertion sequence , bacteria , genome , transposable element , paleontology

The blaIMP-14 carbapenem resistance gene has largely previously been observed in Pseudomonas aeruginosa and Acinetobacter spp. As part of global surveillance and sequencing of carbapenem-resistant Escherichia coli, we identified a sequence type 131 strain harboring blaIMP-14 within a class 1 integron, itself nested within an ∼54-kb multidrug resistance region on an epidemic IncA/C2 plasmid. The emergence of blaIMP-14 in this context in the ST131 lineage is of potential clinical concern.

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