Evaluation of the Gradient Concentration Strip Method for Antifungal Susceptibility Testing of Isavuconazole and Comparators for Mucorales Species | Zendy

Pauline Vidal | Zendy; Patrick Schwarz | Zendy; Éric Dannaoui | Zendy

Open Access

Evaluation of the Gradient Concentration Strip Method for Antifungal Susceptibility Testing of Isavuconazole and Comparators for Mucorales Species

Author(s) -

Pauline Vidal,

Patrick Schwarz,

Éric Dannaoui

Publication year - 2019

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.00838-19

Subject(s) - posaconazole , mucorales , itraconazole , amphotericin b , antifungal , biology , microbiology and biotechnology , mucormycosis , medicine , surgery

MIC values for amphotericin B and three azoles determined by the EUCAST reference technique and by gradient concentration strips were compared for 30Mucorales isolates belonging to clinically important species. Essential agreement (EA) within ±2 dilution steps at 24 hours between the techniques was 83.3% for isavuconazole. EAs for itraconazole, amphotericin B, and posaconazole were 86.7%, 73.3%, and 56.7%, respectively.

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