Determining the Optimal Carbapenem MIC That Distinguishes Carbapenemase-Producing and Non-Carbapenemase-Producing Carbapenem-Resistant Enterobacteriaceae | Zendy

Pranita D. Tamma | Zendy; Yanjie Huang | Zendy; Belita N. A. Opene | Zendy; Patricia J. Simner | Zendy

Open Access

Determining the Optimal Carbapenem MIC That Distinguishes Carbapenemase-Producing and Non-Carbapenemase-Producing Carbapenem-Resistant Enterobacteriaceae

Author(s) -

Pranita D. Tamma,

Yanjie Huang,

Belita N. A. Opene,

Patricia J. Simner

Publication year - 2016

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.00838-16

Subject(s) - ertapenem , doripenem , carbapenem , meropenem , carbapenem resistant enterobacteriaceae , enterobacteriaceae , imipenem , microbiology and biotechnology , biology , antibiotics , klebsiella pneumoniae , antibiotic resistance , escherichia coli , gene , genetics

Carbapenemase-producing (CP)Enterobacteriaceae are largely responsible for the rapid spread of carbapenem-resistantEnterobacteriaceae (CRE). Distinguishing CP-CRE from non-CP-CRE has important infection control implications. In a cohort of 198 CRE isolates, for isolates that remained susceptible or intermediate to some carbapenem antibiotics, an ertapenem MIC of 0.5 μg/ml and meropenem, imipenem, and doripenem MICs of 2 μg/ml were best able to distinguish CP-CRE from non-CP-CRE isolates.

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