In Vitro Spectrum of Activity of Finafloxacin, a Novel, pH-Activated Fluoroquinolone, under Standard and Acidic Conditions | Zendy

Will Stubbings | Zendy; Pamela Leow | Zendy; Goh Chee Yong | Zendy; Falicia Goh | Zendy; Barbara Körber-Irrgang | Zendy; Michael Kresken | Zendy; Rainer Endermann | Zendy; Harald Labischinski | Zendy

Open Access

In Vitro Spectrum of Activity of Finafloxacin, a Novel, pH-Activated Fluoroquinolone, under Standard and Acidic Conditions

Author(s) -

Will Stubbings,

Pamela Leow,

Goh Chee Yong,

Falicia Goh,

Barbara Körber-Irrgang,

Michael Kresken,

Rainer Endermann,

Harald Labischinski

Publication year - 2011

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.00833-10

Subject(s) - antibacterial activity , in vitro , bacteria , chemistry , microbiology and biotechnology , antibacterial agent , nuclear chemistry , biochemistry , antibiotics , biology , genetics

Finafloxacin is a novel fluoroquinolone that exhibits enhanced antibacterial activity under acidic conditions. The aim of this study was to define the in vitro pH-activity relationship. Finafloxacin exhibited optimal antibacterial activity between pH 5.0 and 6.0 at which MICs were 4- to 8-fold lower than those determined at neutral pH. These observations were then confirmed against a larger collection of bacteria. These data suggest that finafloxacin could potentially offer a therapeutic advantage within acidic foci of infection.

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