Serotype and Clonal Evolution of Penicillin-Nonsusceptible Invasive Streptococcus pneumoniae in the 7-Valent Pneumococcal Conjugate Vaccine Era in Italy | Zendy

Giovanni Gherardi | Zendy; Fabio D’Ambrosio | Zendy; Daniela Visaggio | Zendy; Giordano Dicuonzo | Zendy; María Del Grosso | Zendy; Annalisa Pantosti | Zendy

Open Access

Serotype and Clonal Evolution of Penicillin-Nonsusceptible Invasive Streptococcus pneumoniae in the 7-Valent Pneumococcal Conjugate Vaccine Era in Italy

Author(s) -

Giovanni Gherardi,

Fabio D’Ambrosio,

Daniela Visaggio,

Giordano Dicuonzo,

María Del Grosso,

Annalisa Pantosti

Publication year - 2012

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.00830-12

Subject(s) - streptococcus pneumoniae , pneumococcal conjugate vaccine , penicillin , serotype , microbiology and biotechnology , conjugate vaccine , virology , pneumococcal infections , biology , antibiotic resistance , penicillin resistance , antibiotics

The percentage of invasive penicillin-nonsusceptible pneumococci (PNSSP) isolated in Italy in the seven-valent pneumococcal conjugate vaccine (PCV7) era moderately increased in comparison to the pre-PCV7 era. Increase of nonvaccine serotypes was observed among PNSSP. The most frequent PNSSP clones were the same as those identified in the pre-PCV7 era, although they were present in different proportions. Clonal expansion, emergence of new clones, and acquisition of penicillin resistance by established clones contributed to the maintenance of penicillin resistance.

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