Interaction between Posaconazole and Caspofungin in Concomitant Treatment of Mice with Systemic Aspergillus Infection | Zendy

Anthony Cacciapuoti | Zendy; Judith Halpern | Zendy; Cara Mendrick | Zendy; Christine Norris | Zendy; Reena Patel | Zendy; David Loebenberg | Zendy

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Interaction between Posaconazole and Caspofungin in Concomitant Treatment of Mice with Systemic Aspergillus Infection

Author(s) -

Anthony Cacciapuoti,

Judith Halpern,

Cara Mendrick,

Christine Norris,

Reena Patel,

David Loebenberg

Publication year - 2006

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.00829-05

Subject(s) - caspofungin , posaconazole , concomitant , aspergillus fumigatus , antagonism , aspergillus flavus , aspergillosis , aspergillus , microbiology and biotechnology , biology , pharmacology , medicine , immunology , amphotericin b , antifungal , receptor

The interaction of posaconazole and caspofungin was evaluated in concomitant treatment of Aspergillus fumigatus (two strains) or A. flavus (one strain) systemic infections in immunocompetent mice. Survival curves for mice treated with the combinations were compared statistically with those for mice treated with the component monotherapies. No antagonism was observed.

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