Open AccessCapability of 11 Antipneumococcal Antibiotics To Select for Resistance by Multistep and Single-Step Methodologies
Author(s) -
Catherine L. Clark,
Klaudia Kosowska-Shick,
Lois M. Ednie,
Peter C. Appelbaum
Publication year - 2007
Publication title -
antimicrobial agents and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.07
H-Index - 259
eISSN - 1070-6283
pISSN - 0066-4804
DOI - 10.1128/aac.00827-07
Subject(s) - telithromycin , moxifloxacin , tigecycline , levofloxacin , microbiology and biotechnology , ceftriaxone , gemifloxacin , antibiotics , imipenem , medicine , clarithromycin , streptococcus pneumoniae , clindamycin , virology , biology , antibiotic resistance
Testing of 12 pneumococcal strains with differing resistotypes [includingtet (M) positive] showed that tigecycline, amoxicillin-clavulanate, imipenem, and ceftriaxone did not select for resistant clones after 50 sequential subcultures. By comparison, azithromycin, clarithromycin, clindamycin, telithromycin, levofloxacin, moxifloxacin, and gemifloxacin did show resistant clones. Tigecycline also yielded a low frequency of resistance in single-step tests compared to all β-lactams, macrolides/ketolides, and quinolones tested.