Capability of 11 Antipneumococcal Antibiotics To Select for Resistance by Multistep and Single-Step Methodologies | Zendy

Catherine L. Clark | Zendy; Klaudia Kosowska-Shick | Zendy; Lois M. Ednie | Zendy; Peter C. Appelbaum | Zendy

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Capability of 11 Antipneumococcal Antibiotics To Select for Resistance by Multistep and Single-Step Methodologies

Author(s) -

Catherine L. Clark,

Klaudia Kosowska-Shick,

Lois M. Ednie,

Peter C. Appelbaum

Publication year - 2007

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.00827-07

Subject(s) - telithromycin , moxifloxacin , tigecycline , levofloxacin , microbiology and biotechnology , ceftriaxone , gemifloxacin , antibiotics , imipenem , medicine , clarithromycin , streptococcus pneumoniae , clindamycin , virology , biology , antibiotic resistance

Testing of 12 pneumococcal strains with differing resistotypes [includingtet (M) positive] showed that tigecycline, amoxicillin-clavulanate, imipenem, and ceftriaxone did not select for resistant clones after 50 sequential subcultures. By comparison, azithromycin, clarithromycin, clindamycin, telithromycin, levofloxacin, moxifloxacin, and gemifloxacin did show resistant clones. Tigecycline also yielded a low frequency of resistance in single-step tests compared to all β-lactams, macrolides/ketolides, and quinolones tested.

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