Open AccessMolecular Mechanism of Flucytosine Resistance in Candida lusitaniae : Contribution of the FCY2 , FCY1 , and FUR1 Genes to 5-Fluorouracil and Fluconazole Cross-Resistance
Author(s) -
Nicolas Papon,
Thierry Noël,
Martine Florent,
Stéphanie GibotLeclerc,
Dorothée Jean,
Christiane Chastin,
Jean Villard,
Florence Chapeland-Leclerc
Publication year - 2007
Publication title -
antimicrobial agents and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.07
H-Index - 259
eISSN - 1070-6283
pISSN - 0066-4804
DOI - 10.1128/aac.00824-06
Subject(s) - flucytosine , cytosine , cytosine deaminase , biology , fluconazole , uracil , mutant , gene , microbiology and biotechnology , cross resistance , genetics , dna , antifungal , genetic enhancement
Inactivation of the FCY2 (cytosine permease), FCY1 (cytosine deaminase), and FUR1 (uracil phosphoribosyltransferase) genes in Candida lusitaniae produced two patterns of resistance to flucytosine. Mutant fur1 demonstrated resistance to 5-fluorouracil, whereas mutants fcy1 and fcy2 demonstrated fluconazole resistance in the presence of subinhibitory flucytosine concentrations.