Use of Translational Pharmacokinetic/Pharmacodynamic Infection Models To Understand the Impact of Neutropenia on the Efficacy of Tedizolid Phosphate | Zendy

Jianying Xiao | Zendy; Charles Gill | Zendy; Lianzhu Liang | Zendy; Jenny Liu | Zendy; Jin Wu | Zendy; Hwa-ping Feng | Zendy; Shawn Flanagan | Zendy; Christopher M. Tan | Zendy; Amy Flattery | Zendy

Open Access

Use of Translational Pharmacokinetic/Pharmacodynamic Infection Models To Understand the Impact of Neutropenia on the Efficacy of Tedizolid Phosphate

Author(s) -

Jianying Xiao,

Charles Gill,

Lianzhu Liang,

Jenny Liu,

Jin Wu,

Hwa-ping Feng,

Shawn Flanagan,

Christopher M. Tan,

Amy Flattery

Publication year - 2018

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.00822-18

Subject(s) - linezolid , pharmacodynamics , medicine , pharmacokinetics , neutropenia , staphylococcus aureus , pharmacology , antibiotics , methicillin resistant staphylococcus aureus , potency , microbiology and biotechnology , chemistry , biology , toxicity , vancomycin , bacteria , in vitro , biochemistry , genetics

Tedizolid phosphate, the prodrug of the active antibiotic tedizolid, is an oxazolidinone for the treatment of acute bacterial skin and skin structure infections. Studies in a mouse thigh infection model demonstrated that tedizolid has improved potency and pharmacokinetics/pharmacodynamics (PK/PD) compared with those of linezolid.

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