Open Accesscis - and trans -Acting Factors Influence Expression of the norM -Encoded Efflux Pump of Neisseria gonorrhoeae and Levels of Gonococcal Susceptibility to Substrate Antimicrobials
Author(s) -
Corinne E. Rouquette-Loughlin,
Vijaya Dhulipala,
Jennifer L. Reimche,
Erica L. Raterman,
Afrin A. Begum,
Ann E. Jerse,
William M. Shafer
Publication year - 2018
Publication title -
antimicrobial agents and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.07
H-Index - 259
eISSN - 1070-6283
pISSN - 0066-4804
DOI - 10.1128/aac.00821-18
Subject(s) - neisseria gonorrhoeae , efflux , antimicrobial , neisseriaceae , microbiology and biotechnology , gonococcal infection , biology , chemistry , antibiotics , virology , sexually transmitted disease , biochemistry , syphilis , human immunodeficiency virus (hiv)
The gonococcal NorM efflux pump exports substrates with a cationic moiety, including quaternary ammonium compounds such as berberine (BE) and ethidium bromide (EB) as well as antibiotics such as ciprofloxacin and solithromycin. ThenorM gene is part of a four-gene operon that is transcribed from a promoter containing a polynucleotide tract of 6 or 7 thymidines (T's) between the −10 and −35 hexamers; the majority of gonococcal strains analyzed in this study contained a T-6 sequence.
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