Open AccessDrug Resistance Mutation Profile and Accumulation Kinetics in Human Immunodeficiency Virus-Positive Individuals Infected with Subtypes B and F Failing Highly Active Antiretroviral Therapy Are Influenced by Different Viral Codon Usage Patterns
Author(s) -
A. Waléria-Aleixo,
Angélica N. Martins,
Monica Barcelos Arruda,
Rodrigo Brindeiro,
R. M. Da-Silva,
Flávio Fonseca Nobre,
Dirceu Bartolomeu Greco,
Amílcar Tanuri
Publication year - 2008
Publication title -
antimicrobial agents and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.07
H-Index - 259
eISSN - 1070-6283
pISSN - 0066-4804
DOI - 10.1128/aac.00820-08
Subject(s) - virology , biology , mutation , drug resistance , lentivirus , virus , recombinant dna , resistance mutation , viral disease , human immunodeficiency virus (hiv) , sida , immunology , genetics , rna , reverse transcriptase , gene
The major human immunodeficiency virus type 1 subtype circulating in Brazil is B, followed by F and C. We have genotyped 882 samples from Brazilian patients for whom highly active antiretroviral therapy failed, and we found subtype B and the unique recombinant B/F1 forms circulating. Due to codon usage variation, there is a significantly lower incidence of the substitutions L210W, Q151M, and F116Y in subtype F1 isolates than in the subtype B counterparts.