Drug Resistance Mutation Profile and Accumulation Kinetics in Human Immunodeficiency Virus-Positive Individuals Infected with Subtypes B and F Failing Highly Active Antiretroviral Therapy Are Influenced by Different Viral Codon Usage Patterns | Zendy

A. Waléria-Aleixo | Zendy; Angélica N. Martins | Zendy; Mônica Arruda | Zendy; Rodrigo Brindeiro | Zendy; R DASILVA | Zendy; Flávio Fonseca Nobre | Zendy; Dirceu Bartolomeu Greco | Zendy; Amílcar Tanuri | Zendy

Open Access

Drug Resistance Mutation Profile and Accumulation Kinetics in Human Immunodeficiency Virus-Positive Individuals Infected with Subtypes B and F Failing Highly Active Antiretroviral Therapy Are Influenced by Different Viral Codon Usage Patterns

Author(s) -

A. Waléria-Aleixo,

Angélica N. Martins,

Mônica Arruda,

Rodrigo Brindeiro,

R DASILVA,

Flávio Fonseca Nobre,

Dirceu Bartolomeu Greco,

Amílcar Tanuri

Publication year - 2008

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.00820-08

Subject(s) - virology , biology , mutation , drug resistance , lentivirus , virus , recombinant dna , resistance mutation , viral disease , human immunodeficiency virus (hiv) , sida , immunology , genetics , rna , reverse transcriptase , gene

The major human immunodeficiency virus type 1 subtype circulating in Brazil is B, followed by F and C. We have genotyped 882 samples from Brazilian patients for whom highly active antiretroviral therapy failed, and we found subtype B and the unique recombinant B/F1 forms circulating. Due to codon usage variation, there is a significantly lower incidence of the substitutions L210W, Q151M, and F116Y in subtype F1 isolates than in the subtype B counterparts.

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