Molecular Characterization of Nasal Methicillin-Resistant Staphylococcus aureus Isolates Showing Increasing Prevalence of Mupirocin Resistance and Associated Multidrug Resistance following Attempted Decolonization | Zendy

T.T. Poovelikunnel | Zendy; Paulo Eduardo Budri | Zendy; Anna C. Shore | Zendy; David C. Coleman | Zendy; H. Humphreys | Zendy; Deirdre FitzgeraldHughes | Zendy

Open Access

Molecular Characterization of Nasal Methicillin-Resistant Staphylococcus aureus Isolates Showing Increasing Prevalence of Mupirocin Resistance and Associated Multidrug Resistance following Attempted Decolonization

Author(s) -

T.T. Poovelikunnel,

Paulo Eduardo Budri,

Anna C. Shore,

David C. Coleman,

H. Humphreys,

Deirdre FitzgeraldHughes

Publication year - 2018

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.00819-18

Subject(s) - mupirocin , staphylococcus aureus , antiseptic , microbiology and biotechnology , medicine , methicillin resistant staphylococcus aureus , multiple drug resistance , micrococcaceae , antimicrobial , staphylococcal infections , antibiotics , antibacterial agent , biology , bacteria , pathology , genetics

Sequential methicillin-resistant Staphylococcus aureus (MRSA) isolates from patients following attempted mupirocin nasal decolonization showed an increase in mupirocin resistance (MR) from 6.6% to 20%. MR isolates from patients who failed decolonization yielded indistinguishable spa types and carried multiple antimicrobial and antiseptic resistance genes, which may guide infection control and prevention.

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