Lacticin Q-Mediated Selective Toxicity Depending on Physicochemical Features of Membrane Components | Zendy

Fuminori Yoneyama | Zendy; Kanako Ohno | Zendy; Y. Imura | Zendy; Mengqi Li | Zendy; Takeshi Zendo | Zendy; Jiro Nakayama | Zendy; Katsumi Matsuzaki | Zendy; Kenji Sonomoto | Zendy

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Lacticin Q-Mediated Selective Toxicity Depending on Physicochemical Features of Membrane Components

Author(s) -

Fuminori Yoneyama,

Kanako Ohno,

Y. Imura,

Mengqi Li,

Takeshi Zendo,

Jiro Nakayama,

Katsumi Matsuzaki,

Kenji Sonomoto

Publication year - 2011

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.00808-10

Subject(s) - bacteria , bacterial outer membrane , bacteriocin , membrane , gram negative bacteria , membrane permeability , gram positive bacteria , biochemistry , chemistry , biology , biophysics , escherichia coli , genetics , gene

Lacticin Q, a lactococcal pore-forming bacteriocin, shows activity toward Gram-positive bacteria but not Gram-negative bacteria. Lacticin Q did not induce permeability of the outer membrane of Gram-negative bacteria. Experiments using model membranes containing outer membrane components suggested that lacticin Q binds to the outer membrane of Gram-negative bacteria but is unable to penetrate it. The lack of activity of lacticin Q was attributed to physicochemical features of the outer membrane components.

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