RNAIII-Inhibiting Peptide Affects Biofilm Formation in a Rat Model of Staphylococcal Ureteral Stent Infection | Zendy

Oscar Cirioni | Zendy; Roberto Ghiselli | Zendy; Daniele Minardi | Zendy; Fiorenza Orlando | Zendy; Federico Mocchegiani | Zendy; Carmela Silvestri | Zendy; Giovanni Muzzonigro | Zendy; Vittorio Saba | Zendy; Giorgio Scalise | Zendy; Naomi Balaban | Zendy; Andrea Giacometti | Zendy

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RNAIII-Inhibiting Peptide Affects Biofilm Formation in a Rat Model of Staphylococcal Ureteral Stent Infection

Author(s) -

Oscar Cirioni,

Roberto Ghiselli,

Daniele Minardi,

Fiorenza Orlando,

Federico Mocchegiani,

Carmela Silvestri,

Giovanni Muzzonigro,

Vittorio Saba,

Giorgio Scalise,

Naomi Balaban,

Andrea Giacometti

Publication year - 2007

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.00808-07

Subject(s) - stent , biofilm , quorum sensing , staphylococcus aureus , teicoplanin , peptide , microbiology and biotechnology , medicine , chemistry , biology , biochemistry , bacteria , vancomycin , genetics

Ureteral stents coated with the quorum-sensing inhibitor RNAIII-inhibiting peptide (RIP) were implanted in rat bladders and shown to suppress Staphylococcus aureus formation on the stent and in urine and was especially effective when combined with teicoplanin. Coating ureteral stents with RIP thus increases the efficacy of teicoplanin in preventing ureteral stent-associated staphylococcal infections.

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