The Siderophore Transporter Sit1 Determines Susceptibility to the Antifungal VL-2397 | Zendy

AnnaMaria Dietl | Zendy; Matthias Misslinger | Zendy; Mario Aguiar | Zendy; Vasyl Ivashov | Zendy; David Teis | Zendy; Joachim Pfister | Zendy; Clemens Decristoforo | Zendy; Martin Hermann | Zendy; Seán M. Sullivan | Zendy; Larry Smith | Zendy; Hubertus Haas | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

The Siderophore Transporter Sit1 Determines Susceptibility to the Antifungal VL-2397

Author(s) -

AnnaMaria Dietl,

Matthias Misslinger,

Mario Aguiar,

Vasyl Ivashov,

David Teis,

Joachim Pfister,

Clemens Decristoforo,

Martin Hermann,

Seán M. Sullivan,

Larry Smith,

Hubertus Haas

Publication year - 2019

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.00807-19

Subject(s) - aspergillus fumigatus , siderophore , candida glabrata , microbiology and biotechnology , biology , saccharomyces cerevisiae , chemistry , antifungal , biochemistry , gene

VL-2397 (previously termed ASP2397) is an antifungal, aluminum-chelating cyclic hexapeptide with a structure analogous to that of ferrichrome-type siderophores, whereby replacement of aluminum by iron was shown to decrease the antifungal activity of this compound. Here, we found that inactivation of an importer for ferrichrome-type siderophores, termed Sit1, rendersAspergillus fumigatus resistant to VL-2397.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research