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VL-2397 (previously termed ASP2397) is an antifungal, aluminum-chelating cyclic hexapeptide with a structure analogous to that of ferrichrome-type siderophores, whereby replacement of aluminum by iron was shown to decrease the antifungal activity of this compound. Here, we found that inactivation of an importer for ferrichrome-type siderophores, termed Sit1, rendersAspergillus fumigatus resistant to VL-2397.

The Siderophore Transporter Sit1 Determines Susceptibility to the Antifungal VL-2397