Daptomycin In Vitro Activity against Methicillin-Resistant Staphylococcus aureus Is Enhanced by d -Cycloserine in a Mechanism Associated with a Decrease in Cell Surface Charge | Zendy

Oriol Gasch | Zendy; Satish K. Pillai | Zendy; Joanna Dakos | Zendy; Spiros Miyakis | Zendy; Robert C. Moellering | Zendy; George M. Eliopoulos | Zendy

Open Access

Daptomycin In Vitro Activity against Methicillin-Resistant Staphylococcus aureus Is Enhanced by d -Cycloserine in a Mechanism Associated with a Decrease in Cell Surface Charge

Author(s) -

Oriol Gasch,

Satish K. Pillai,

Joanna Dakos,

Spiros Miyakis,

Robert C. Moellering,

George M. Eliopoulos

Publication year - 2013

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.00799-13

Subject(s) - daptomycin , staphylococcus aureus , microbiology and biotechnology , methicillin resistant staphylococcus aureus , in vitro , antibacterial agent , cycloserine , strain (injury) , chemistry , vancomycin , bacteria , antibiotics , biology , biochemistry , anatomy , genetics

The killing activity of daptomycin against an isogenic pair of daptomycin-susceptible and daptomycin-nonsusceptible (DNS) methicillin-resistant Staphylococcus aureus (MRSA) strains was enhanced by the addition of certain cell wall agents at 1× MIC. However, when high inocula of the DNS strain were used, no significant killing was observed in our experiments. Cytochrome c binding assays revealed d-cycloserine as the only agent associated with a reduction in the cell surface charge for both strains at the concentrations used.

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