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We aimed to describe thein vivo activity of humanized pharmacokinetic exposures of meropenem and comparators against Verona integron-encoded metallo-β-lactamase (MBL) (VIM)-producingEnterobacteriaceae in a murine model. Levofloxacin activity was predicted by its MIC, and cefepime activity displayed variability, whereas meropenem produced a &gt;1 log CFU reduction against all isolates despite high MICs indicative of resistance. Our results suggest that despitein vitro resistance, high-dose meropenem may be a possible option against infections caused byEnterobacteriaceae producing MBL-type carbapenemases.

antimicrobial agents and chemotherapy

Efficacy of Humanized High-Dose Meropenem, Cefepime, and Levofloxacin against Enterobacteriaceae Isolates Producing Verona Integron-Encoded Metallo-β-Lactamase (VIM) in a Murine Thigh Infection Model