Activity of Aromathecins against African Trypanosomes | Zendy

Nathaniel P. Nenortas | Zendy; Maris A. Cinelli | Zendy; Andrew Morrell | Zendy; Mark Cushman | Zendy; Theresa A. Shapiro | Zendy

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Activity of Aromathecins against African Trypanosomes

Author(s) -

Nathaniel P. Nenortas,

Maris A. Cinelli,

Andrew Morrell,

Mark Cushman,

Theresa A. Shapiro

Publication year - 2018

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.00786-18

Subject(s) - trypanosoma brucei , antiparasitic , topoisomerase , african trypanosomiasis , potency , kinetoplastida , biology , protozoa , dna , trypanosoma , trypanocidal agent , pharmacology , virology , biochemistry , microbiology and biotechnology , trypanosomiasis , in vitro , protozoal disease , immunology , malaria , medicine , gene , pathology

African sleeping sickness is responsible for thousands of deaths annually, and new therapeutics are needed. This study evaluated aromathecins, experimental inhibitors of mammalian topoisomerase IB, againstTrypanosoma brucei African trypanosomes.

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