Defects in Efflux ( oprM ), β-Lactamase ( ampC ), and Lipopolysaccharide Transport ( lptE ) Genes Mediate Antibiotic Hypersusceptibility of Pseudomonas aeruginosa Strain Z61 | Zendy

Xiaoyu Shen | Zendy; Nicole V. Johnson | Zendy; Naomi N. K. Kreamer | Zendy; S. Whitney Barnes | Zendy; John R. Walker | Zendy; Angela Woods | Zendy; David A. Six | Zendy; Charles R. Dean | Zendy

Open Access

Defects in Efflux ( oprM ), β-Lactamase ( ampC ), and Lipopolysaccharide Transport ( lptE ) Genes Mediate Antibiotic Hypersusceptibility of Pseudomonas aeruginosa Strain Z61

Author(s) -

Xiaoyu Shen,

Nicole V. Johnson,

Naomi N. K. Kreamer,

S. Whitney Barnes,

John R. Walker,

Angela Woods,

David A. Six,

Charles R. Dean

Publication year - 2019

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.00784-19

Subject(s) - pseudomonas aeruginosa , efflux , microbiology and biotechnology , escherichia coli , mutant , antibiotics , strain (injury) , biology , mutagenesis , antibacterial agent , gene , lipopolysaccharide , bacteria , genetics , anatomy , endocrinology

Antibiotic hypersensitive bacterial mutants (e.g.,Escherichia coli imp ) are used to investigate intrinsic resistance and are exploited in antibacterial discovery to track weak antibacterial activity of novel inhibitor compounds.Pseudomonas aeruginosa Z61 is one such drug-hypersusceptible strain generated by chemical mutagenesis, although the genetic basis for hypersusceptibility is not fully understood.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research