Differential Adaptive Responses of Staphylococcus aureus to In Vitro Selection with Different Antimicrobial Peptides | Zendy

Tahsina Shireen | Zendy; Madhuri Singh | Zendy; Tiyasa Das | Zendy; Kasturi Mukhopadhyay | Zendy

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Differential Adaptive Responses of Staphylococcus aureus to In Vitro Selection with Different Antimicrobial Peptides

Author(s) -

Tahsina Shireen,

Madhuri Singh,

Tiyasa Das,

Kasturi Mukhopadhyay

Publication year - 2013

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.00780-13

Subject(s) - staphylococcus aureus , antimicrobial , microbiology and biotechnology , antimicrobial peptides , in vitro , biology , selection (genetic algorithm) , differential (mechanical device) , antibacterial agent , antibiotics , bacteria , genetics , computer science , artificial intelligence , engineering , aerospace engineering

We subjected Staphylococcus aureus ATCC 29213 to serial passage in the presence of subinhibitory concentrations of magainin 2 and gramicidin D for several hundred generations. We obtained S. aureus strains with induced resistance to magainin 2 (strain 55MG) and gramicidin D (strain 55GR) that showed different phenotypic changes in membrane properties. Both exhibited a change in membrane phospholipid content and an increase in membrane rigidity, while an alteration in net charge compared to that of the control occurred only in the case of 55MG.

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