Open AccessFirst Report of Plasmid-Mediated qnrA1 in a Ciprofloxacin-Resistant Escherichia coli Strain in Latin America
Author(s) -
Mariana Castanheira,
Andrea S. Pereira,
Adriana G. Nicoletti,
Antônio Carlos Campos Pignatari,
Afonso Luís Barth,
Ana Cristina Gales
Publication year - 2007
Publication title -
antimicrobial agents and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.07
H-Index - 259
eISSN - 1070-6283
pISSN - 0066-4804
DOI - 10.1128/aac.00780-06
Subject(s) - integron , plasmid , escherichia coli , ciprofloxacin , microbiology and biotechnology , strain (injury) , biology , enterobacteriaceae , gene , antibacterial agent , genetics , antibiotics , anatomy
Among 144 ciprofloxacin-resistant Escherichia coli isolated in Brazil, one (0.69%) QnrA1-producing isolate was detected. The qnrA1 gene was associated with ISCR1. The QnrA1 determinant was carried on a 41-kb conjugative plasmid, which also carried a FOX-type cephalosporinase encoding gene and a class 1 integron with the aadB and catB3 cassettes. This is the first report of a qnrA-carrying isolate in a Latin American country.