First Report of Plasmid-Mediated qnrA1 in a Ciprofloxacin-Resistant Escherichia coli Strain in Latin America | Zendy

Mariana Castanheira | Zendy; Andrea S. Pereira | Zendy; Adriana G. Nicoletti | Zendy; Antônio Carlos Campos Pignatari | Zendy; Afonso Luís Barth | Zendy; Ana Cristina Gales | Zendy

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First Report of Plasmid-Mediated qnrA1 in a Ciprofloxacin-Resistant Escherichia coli Strain in Latin America

Author(s) -

Mariana Castanheira,

Andrea S. Pereira,

Adriana G. Nicoletti,

Antônio Carlos Campos Pignatari,

Afonso Luís Barth,

Ana Cristina Gales

Publication year - 2007

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.00780-06

Subject(s) - integron , plasmid , escherichia coli , ciprofloxacin , microbiology and biotechnology , strain (injury) , biology , enterobacteriaceae , gene , antibacterial agent , genetics , antibiotics , anatomy

Among 144 ciprofloxacin-resistant Escherichia coli isolated in Brazil, one (0.69%) QnrA1-producing isolate was detected. The qnrA1 gene was associated with ISCR1. The QnrA1 determinant was carried on a 41-kb conjugative plasmid, which also carried a FOX-type cephalosporinase encoding gene and a class 1 integron with the aadB and catB3 cassettes. This is the first report of a qnrA-carrying isolate in a Latin American country.

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