Effect of Pulmonary Surfactant on Antimicrobial Activity In Vitro | Zendy

Richard Schwameis | Zendy; Zeynep Erdogan-Yildirim | Zendy; Mohammad Manafi | Zendy; Markus Zeitlinger | Zendy; Sabine Strommer | Zendy; Robert Sauermann | Zendy

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Effect of Pulmonary Surfactant on Antimicrobial Activity In Vitro

Author(s) -

Richard Schwameis,

Zeynep Erdogan-Yildirim,

Mohammad Manafi,

Markus Zeitlinger,

Sabine Strommer,

Robert Sauermann

Publication year - 2013

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.00778-13

Subject(s) - doripenem , colistin , moxifloxacin , antimicrobial , tigecycline , medicine , linezolid , pseudomonas aeruginosa , microbiology and biotechnology , antibiotics , pulmonary surfactant , staphylococcus aureus , sparfloxacin , pharmacology , chemistry , meropenem , biology , antibiotic resistance , bacteria , vancomycin , biochemistry , genetics , ofloxacin , ciprofloxacin

Time-kill curve experiments were performed with linezolid, doripenem, tigecycline, moxifloxacin, and daptomycin against Staphylococcus aureus and with colistin, moxifloxacin, and doripenem against Pseudomonas aeruginosa to evaluate the effect of porcine pulmonary surfactant on antimicrobial activity. Pulmonary surfactant significantly impaired the activities of moxifloxacin and colistin. When antibiotics are being developed for respiratory tract infections, the method described here might be used to preliminarily quantify the effect of pulmonary surfactant on antimicrobial activity.

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