In Vitro and In Vivo Biological Activities of Iron Chelators and Gallium Nitrate against Acinetobacter baumannii | Zendy

Louis de Léséleuc | Zendy; Greg Harris | Zendy; Rhonda KuoLee | Zendy; Wangxue Chen | Zendy

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In Vitro and In Vivo Biological Activities of Iron Chelators and Gallium Nitrate against Acinetobacter baumannii

Author(s) -

Louis de Léséleuc,

Greg Harris,

Rhonda KuoLee,

Wangxue Chen

Publication year - 2012

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.00778-12

Subject(s) - acinetobacter baumannii , transferrin , gallium , in vivo , microbiology and biotechnology , in vitro , nitrate , biology , chemistry , pharmacology , biochemistry , bacteria , pseudomonas aeruginosa , genetics , ecology , organic chemistry

We investigated the ability of compounds interfering with iron metabolism to inhibit the growth of Acinetobacter baumannii. Iron restriction with transferrin or 2,2-bipyridyl significantly inhibited A. baumannii growth in vitro. Gallium nitrate alone was moderately effective at reducing A. baumannii growth but became bacteriostatic in the presence of serum or transferrin. More importantly, gallium nitrate treatment reduced lung bacterial burdens in mice. The use of gallium-based therapies shows promise for the control of multidrug-resistant A. baumannii.

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