Complete Nucleotide Sequence of an IncI2 Plasmid Coharboring bla CTX-M-55 and mcr-1 | Zendy

Jian Sun | Zendy; XingPing Li | Zendy; Runshi Yang | Zendy; LiangXing Fang | Zendy; Wei Huo | Zendy; Shumin Li | Zendy; Peng Jiang | Zendy; XiaoPing Liao | Zendy; Ya-Hong Liu | Zendy

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Complete Nucleotide Sequence of an IncI2 Plasmid Coharboring bla _CTX-M-55 and mcr-1

Author(s) -

Jian Sun,

XingPing Li,

Runshi Yang,

LiangXing Fang,

Wei Huo,

Shumin Li,

Peng Jiang,

XiaoPing Liao,

Ya-Hong Liu

Publication year - 2016

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.00774-16

Subject(s) - plasmid , replicon , nucleic acid sequence , biology , sequence (biology) , escherichia coli , genetics , gene , insertion sequence , nucleotide , microbiology and biotechnology , enterobacteriaceae , transposable element , genome

We report the complete nucleotide sequence of a plasmid, pA31-12, carrying blaCTX-M-55 and mcr-1 from a chicken Escherichia coli isolate. pA31-12 has an IncI2 replicon that displays extensive sequence similarity with pHN1122-1-borne blaCTX-M-55 and pHNSHP45-borne mcr-1 Insertion sequences ISEcp1 and ISApl1 are responsible for the mobilization of blaCTX-M-55 and mcr-1, respectively. The colocalization of mcr-1 with an extended-spectrum β-lactamase gene on a conjugative plasmid may accelerate the dissemination of both genes by coselection.

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