Open AccessThe Natural Stilbenoid (–)-Hopeaphenol Inhibits Cellular Entry of SARS-CoV-2 USA-WA1/2020, B.1.1.7, and B.1.351 Variants
Author(s) -
Ian Tietjen,
Joel Cassel,
Emery Register,
Xiang Zhou,
Troy E. Messick,
Frederick Keeney,
Lily Lu,
Karren D. Beattie,
Topul Rali,
Pablo Tebas,
Hildegund C. J. Ertl,
Joseph M. Salvino,
Rohan A. Davis,
Luis J. Montaner
Publication year - 2021
Publication title -
antimicrobial agents and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.07
H-Index - 259
eISSN - 1070-6283
pISSN - 0066-4804
DOI - 10.1128/aac.00772-21
Subject(s) - viral entry , vero cell , ic50 , cytotoxicity , biology , binding site , viral replication , receptor , virology , chemistry , virus , in vitro , biochemistry
Antivirals are urgently needed to combat the global SARS-CoV-2/COVID-19 pandemic, supplement existing vaccine efforts, and target emerging SARS-CoV-2 variants of concern. Small molecules that interfere with binding of the viral spike receptor binding domain (RBD) to the host angiotensin-converting enzyme II (ACE2) receptor may be effective inhibitors of SARS-CoV-2 cell entry.