In Vitro Activity of Ceftolozane-Tazobactam and Other Antimicrobial Agents against Burkholderia cepacia Complex and Burkholderia gladioli | Zendy

Dale M. Mazer | Zendy; Carol Young | Zendy; Linda M. Kalikin | Zendy; Theodore Spilker | Zendy; John J. LiPuma | Zendy

Open Access

In Vitro Activity of Ceftolozane-Tazobactam and Other Antimicrobial Agents against Burkholderia cepacia Complex and Burkholderia gladioli

Author(s) -

Dale M. Mazer,

Carol Young,

Linda M. Kalikin,

Theodore Spilker,

John J. LiPuma

Publication year - 2017

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.00766-17

Subject(s) - burkholderia , antimicrobial , microbiology and biotechnology , burkholderia cepacia complex , in vitro , biology , bacteria , biochemistry , genetics

We tested the activities of ceftolozane-tazobactam and 13 other antimicrobial agents against 221 strains ofBurkholderia cepacia complex andBurkholderia gladioli . Most strains (82%) were cultured from persons with cystic fibrosis, and most (85%) were recovered since 2011. The ceftolozane-tazobactam MIC was ≤8 μg/ml for 77% of the strains. However, the MIC range was broad (≤0.5 to >64 μg/ml; MIC50/90 , 2/32 μg/ml). Significant differences in susceptibility to some antimicrobial agents were observed between species.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research