Colistin Heteroresistance in Acinetobacter and Its Association with Previous Colistin Therapy | Zendy

Joshua S. Hawley | Zendy; Clinton K. Murray | Zendy; James H. Jorgensen | Zendy

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Colistin Heteroresistance in Acinetobacter and Its Association with Previous Colistin Therapy

Author(s) -

Joshua S. Hawley,

Clinton K. Murray,

James H. Jorgensen

Publication year - 2007

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.00766-07

Subject(s) - colistin , acinetobacter , acinetobacter baumannii , microbiology and biotechnology , population , biology , medicine , antibiotics , bacteria , pseudomonas aeruginosa , genetics , environmental health

Colistin heteroresistance has been reported among Acinetobacter isolates; however, its association with prior colistin therapy has not been not described. A population analysis profile identified resistant Acinetobacter subpopulations from colistin-susceptible clinical isolates. The proportion of cells exhibiting heteroresistance was significantly higher among isolates recovered from patients treated with colistin.

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