Emergence and Plasmid Analysis of Klebsiella pneumoniae KP01 Carrying bla GES-5 from Guangzhou, China | Zendy

Dingqiang Chen | Zendy; Aiwu Wu | Zendy; Ling Yang | Zendy; Danhong Su | Zendy; Yongping Lin | Zendy; YanWei Hu | Zendy; Lei Zheng | Zendy; Qian Wang | Zendy

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Emergence and Plasmid Analysis of Klebsiella pneumoniae KP01 Carrying bla _GES-5 from Guangzhou, China

Author(s) -

Dingqiang Chen,

Aiwu Wu,

Ling Yang,

Danhong Su,

Yongping Lin,

YanWei Hu,

Lei Zheng,

Qian Wang

Publication year - 2016

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.00764-16

Subject(s) - klebsiella pneumoniae , plasmid , microbiology and biotechnology , china , biology , enterobacteriaceae , klebsiella infections , klebsiella , virology , escherichia coli , genetics , gene , geography , archaeology

Klebsiella pneumoniae strain KP01 carryingbla GES-5 was identified from a patient in Guangzhou, China. High-throughput sequencing assignedbla GES-5 to a 28.5-kb nonconjugative plasmid, pGES-GZ. A 13-kb plasmid backbone sequence on pGES-GZ was found to share high sequence identities with plasmids from Gram-negative nonfermenters. A novel class 1 integron carrying a gene cassette array oforf28-orf28-bla GES-5 was identified on pGES-GZ, within whichorf28 encoded a hypothetical protein possibly correlated to fosfomycin resistance.

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