GS-5806 Inhibits Pre- to Postfusion Conformational Changes of the Respiratory Syncytial Virus Fusion Protein | Zendy

Dharmaraj Samuel | Zendy; Weimei Xing | Zendy; Anita NiedzielaMajka | Zendy; Jinny S. Wong | Zendy; Magdeleine Hung | Zendy; Katherine M. Brendza | Zendy; Michel Perron | Zendy; Robert Jordan | Zendy; David Sperandio | Zendy; Xiaohong Liu | Zendy; Richard L. Mackman | Zendy; Roman Sakowicz | Zendy

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GS-5806 Inhibits Pre- to Postfusion Conformational Changes of the Respiratory Syncytial Virus Fusion Protein

Author(s) -

Dharmaraj Samuel,

Weimei Xing,

Anita NiedzielaMajka,

Jinny S. Wong,

Magdeleine Hung,

Katherine M. Brendza,

Michel Perron,

Robert Jordan,

David Sperandio,

Xiaohong Liu,

Richard L. Mackman,

Roman Sakowicz

Publication year - 2015

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.00761-15

Subject(s) - virus , lipid bilayer fusion , fusion protein , viral envelope , viral entry , biology , cell fusion , virology , paramyxoviridae , in vitro , pneumovirinae , viral replication , cell , biochemistry , recombinant dna , viral disease , gene

GS-5806 is a small-molecule inhibitor of human respiratory syncytial virus fusion protein-mediated viral entry. During viral entry, the fusion protein undergoes major conformational changes, resulting in fusion of the viral envelope with the host cell membrane. This process is reproduced in vitro using a purified, truncated respiratory syncytial virus (RSV) fusion protein. GS-5806 blocked these conformational changes, suggesting a possible mechanism for antiviral activity.

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