Oritavancin Disrupts Membrane Integrity of Staphylococcus aureus and Vancomycin-Resistant Enterococci To Effect Rapid Bacterial Killing | Zendy

Adam Belley | Zendy; Geoffrey A. McKay | Zendy; Francis F. Arhin | Zendy; Ingrid Sarmiento | Zendy; Sylvain Beaulieu | Zendy; Ibthihal Fadhil | Zendy; Thomas Parr | Zendy; Greg Moeck | Zendy

Open Access

Oritavancin Disrupts Membrane Integrity of Staphylococcus aureus and Vancomycin-Resistant Enterococci To Effect Rapid Bacterial Killing

Author(s) -

Adam Belley,

Geoffrey A. McKay,

Francis F. Arhin,

Ingrid Sarmiento,

Sylvain Beaulieu,

Ibthihal Fadhil,

Thomas Parr,

Greg Moeck

Publication year - 2010

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.00760-10

Subject(s) - staphylococcus aureus , microbiology and biotechnology , enterococcus , vancomycin , daptomycin , methicillin resistant staphylococcus aureus , staphylococcal skin infections , bacteria , biology , chemistry , antibiotics , genetics

Oritavancin is an investigational lipoglycopeptide in clinical development for the treatment of acute bacterial skin and skin structure infections. In this study, we demonstrate that oritavancin causes bacterial membrane depolarization and permeabilization leading to cell death of Gram-positive pathogens and that these effects are attributable to the 4'-chlorobiphenylmethyl group of the molecule.

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