Activities of NXL104 Combinations with Ceftazidime and Aztreonam against Carbapenemase-Producing Enterobacteriaceae | Zendy

David M. Livermore | Zendy; Shazad Mushtaq | Zendy; Marina Warner | Zendy; Jiancheng Zhang | Zendy; Sunil Maharjan | Zendy; Michel Doumith | Zendy; Neil Woodford | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Activities of NXL104 Combinations with Ceftazidime and Aztreonam against Carbapenemase-Producing Enterobacteriaceae

Author(s) -

David M. Livermore,

Shazad Mushtaq,

Marina Warner,

Jiancheng Zhang,

Sunil Maharjan,

Michel Doumith,

Neil Woodford

Publication year - 2010

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.00756-10

Subject(s) - aztreonam , ceftazidime , enterobacteriaceae , microbiology and biotechnology , carbapenem , enzyme , biology , antibiotics , bacteria , imipenem , escherichia coli , antibiotic resistance , biochemistry , pseudomonas aeruginosa , gene , genetics

Combinations of NXL104 with ceftazidime and aztreonam were tested against carbapenem-resistant members of the Enterobacteriaceae. Ceftazidime-NXL104 was active against strains with the OXA-48 enzyme or with combinations of impermeability and an extended-spectrum β-lactamase (ESBL) or AmpC enzyme and also against most Klebsiella spp. with the KPC enzyme, but metallo-β-lactamase producers were resistant. Aztreonam-NXL104 was active against all carbapenemase producers at 4 and 4 μg/ml, including those with metallo-β-lactamases.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research