Open AccessActivities of NXL104 Combinations with Ceftazidime and Aztreonam against Carbapenemase-Producing Enterobacteriaceae
Author(s) -
David M. Livermore,
Shazad Mushtaq,
Marina Warner,
Jiancheng Zhang,
Sunil Maharjan,
Michel Doumith,
Neil Woodford
Publication year - 2011
Publication title -
antimicrobial agents and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.07
H-Index - 259
eISSN - 1070-6283
pISSN - 0066-4804
DOI - 10.1128/aac.00756-10
Subject(s) - aztreonam , ceftazidime , enterobacteriaceae , microbiology and biotechnology , carbapenem , enzyme , biology , antibiotics , bacteria , imipenem , escherichia coli , antibiotic resistance , biochemistry , pseudomonas aeruginosa , gene , genetics
Combinations of NXL104 with ceftazidime and aztreonam were tested against carbapenem-resistant members of the Enterobacteriaceae. Ceftazidime-NXL104 was active against strains with the OXA-48 enzyme or with combinations of impermeability and an extended-spectrum β-lactamase (ESBL) or AmpC enzyme and also against most Klebsiella spp. with the KPC enzyme, but metallo-β-lactamase producers were resistant. Aztreonam-NXL104 was active against all carbapenemase producers at 4 and 4 μg/ml, including those with metallo-β-lactamases.