Changing Epidemiology of Extended-Spectrum β-Lactamases in Argentina: Emergence of CTX-M-15 | Zendy

Samanta Sennati | Zendy; Gisela Santella | Zendy; José Di Conza | Zendy; Lucia Pallecchi | Zendy; M. Pino | Zendy; Bárbara Ghiglione | Zendy; Gian María Rossolini | Zendy; Marcela Rádice | Zendy; Gabriel Gutkind | Zendy

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Changing Epidemiology of Extended-Spectrum β-Lactamases in Argentina: Emergence of CTX-M-15

Author(s) -

Samanta Sennati,

Gisela Santella,

José Di Conza,

Lucia Pallecchi,

M. Pino,

Bárbara Ghiglione,

Gian María Rossolini,

Marcela Rádice,

Gabriel Gutkind

Publication year - 2012

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.00745-12

Subject(s) - klebsiella pneumoniae , epidemiology , molecular epidemiology , escherichia coli , microbiology and biotechnology , enterobacteriaceae , biology , enzyme , medicine , genotype , genetics , gene , biochemistry

A multicenter survey, carried out in 2010 in Argentina, showed an increased prevalence of extended-spectrum β-lactamase (ESBL)-producing enterobacteria, with some changes in the molecular epidemiology of circulating ESBLs. While enzymes of the CTX-M-2 group remain endemic, the emergence of CTX-M-15 and of enzymes of the CTX-M-8 and CTX-M-9 groups was observed. The CTX-M-15-positive isolates represented 40% of CTX-M producers and included representatives of Escherichia coli ST131 and Klebsiella pneumoniae ST11.

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