In Vitro Activity of Isavuconazole against Rasamsonia Species | Zendy

Joerg Steinmann | Zendy; S. Dittmer | Zendy; Jos Houbraken | Zendy; Jan Buer | Zendy; P.-M. Rath | Zendy

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In Vitro Activity of Isavuconazole against Rasamsonia Species

Author(s) -

Joerg Steinmann,

S. Dittmer,

Jos Houbraken,

Jan Buer,

P.-M. Rath

Publication year - 2016

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.00742-16

Subject(s) - voriconazole , echinocandins , in vitro , triazole , antifungal , biology , microbiology and biotechnology , pharmacology , chemistry , caspofungin , biochemistry , organic chemistry

The in vitro susceptibilities to the novel triazole isavuconazole and six other antifungal agents of a large collection of Rasamsonia isolates (n = 47) belonging to seven species were determined. Isavuconazole and voriconazole had no in vitro activity (MIC, >32 mg/liter) against isolates of the Rasamsonia argillacea species complex. The echinocandins were the most potent antifungal drugs against all of the isolates tested (minimum effective concentration, ≤0.19 mg/liter).

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