In Vitro Susceptibility of Breakthrough Candida Bloodstream Isolates Correlates with Daily and Cumulative Doses of Fluconazole | Zendy

Cornelius J. Clancy | Zendy; Benjamin Staley | Zendy; M. Hong Nguyen | Zendy

Open Access

In Vitro Susceptibility of Breakthrough Candida Bloodstream Isolates Correlates with Daily and Cumulative Doses of Fluconazole

Author(s) -

Cornelius J. Clancy,

Benjamin Staley,

M. Hong Nguyen

Publication year - 2006

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.00741-06

Subject(s) - fluconazole , microbiology and biotechnology , in vitro , bloodstream infection , biology , fungemia , medicine , antifungal , genetics

We determined MICs for 28 Candida isolates recovered from patients who developed breakthrough candidemia while receiving fluconazole. MICs correlated with daily and cumulative doses of fluconazole. Patients receiving > or =2,000 mg cumulatively or >200 mg daily were more likely to be infected with isolates that were not fluconazole susceptible.

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