In Vitro Comparison of Nitrofurazone- and Silver Alloy-Coated Foley Catheters for Contact-Dependent and Diffusible Inhibition of Urinary Tract Infection-Associated Microorganisms | Zendy

James R. Johnson | Zendy; Brian Johnston | Zendy; Michael A. Kuskowski | Zendy

Open Access

In Vitro Comparison of Nitrofurazone- and Silver Alloy-Coated Foley Catheters for Contact-Dependent and Diffusible Inhibition of Urinary Tract Infection-Associated Microorganisms

Author(s) -

James R. Johnson,

Brian Johnston,

Michael A. Kuskowski

Publication year - 2012

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.00733-12

Subject(s) - nitrofurazone , microbiology and biotechnology , catheter , biofilm , in vitro , urinary system , antimicrobial , foley catheter , saline , pharmacology , chemistry , medicine , biology , bacteria , surgery , anesthesia , biochemistry , genetics , traditional medicine

Two marketed antimicrobial-coated Foley catheters were compared forin vitro diffusible and contact-dependent inhibition of 11 urinary tract infection-associated microorganisms in an adherence-biofilm assay. Nitrofurazone-coated catheters significantly outperformed silver alloy-coated catheters for inhibitory activity, according to both inoculum broth and catheter sonicate counts, whether compared directly or against the corresponding control catheters. Although inhibition waned with catheter preincubation in saline, some organisms were inhibited even after a 48-h catheter preincubation, especially by the nitrofurazone-coated catheter.

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