Peptide-Based Efflux Pump Inhibitors of the Small Multidrug Resistance Protein from Pseudomonas aeruginosa | Zendy

Chloe J Mitchell | Zendy; Tracy A. Stone | Zendy; Charles M. Deber | Zendy

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Peptide-Based Efflux Pump Inhibitors of the Small Multidrug Resistance Protein from Pseudomonas aeruginosa

Author(s) -

Chloe J Mitchell,

Tracy A. Stone,

Charles M. Deber

Publication year - 2019

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.00730-19

Subject(s) - efflux , pseudomonas aeruginosa , peptide , ethidium bromide , multiple drug resistance , biochemistry , chemistry , peptide sequence , transmembrane domain , biology , microbiology and biotechnology , bacteria , membrane , antibiotics , genetics , dna , gene

Bacteria have acquired multiple mechanisms to evade the lethal effects of current therapeutics, hindering treatment of bacterial infections, such as those caused by the pathogenPseudomonas aeruginosa , which is responsible for nosocomial and cystic fibrosis lung infections. One resistance mechanism involves membrane-embedded multidrug efflux pumps that can effectively extrude an array of substrates, including common antibiotics, dyes, and biocides.

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